Cells chromosomes are composed by DNA molecules which are associated to nucleosomes, transcription factors, and regulative proteins, collectively known as chromatin. Epigenetic modifications are chromatin modifications that influence DNA accessibility, thus triggering genes activation or repression, without modifying the DNA sequence.
Epigenetic modifications following environment or development signals, determine the differentiation, the reprogramming, or the transformation of cells, by altering the genes expression. The transcription of genes in eucharyotes is always coupled to epigenetic changes.
Main aim of our lab is the understanding of the mechanisms controlling the different histone modifications,
and the deciphering of the histone code which contributes to the transcriptional control, to understand
and eventually influence cells destiny.
For this purpose, we combine cellular and molecular biology, and biochemical approaches to obtain whole-genome maps of chromatin regulation patterns in different conditions.